• figaro@lemdro.id
      link
      fedilink
      English
      arrow-up
      5
      ·
      5 months ago

      Man you don’t even know, we probably have immortal mice at this point

  • srasmus@lemmy.world
    link
    fedilink
    English
    arrow-up
    21
    ·
    5 months ago

    I feel like I’ve heard that clearing the tangles really doesn’t affect the trajectory of the disease?

    • SuperIce@lemmy.world
      link
      fedilink
      English
      arrow-up
      25
      ·
      5 months ago

      Yeah, from the article “while many tau-based therapies show promise in animal models, their translation into effective medicine for humans ‘has so far failed.’”.

  • witty_username@feddit.nl
    link
    fedilink
    arrow-up
    19
    ·
    5 months ago

    I’m convinced that the Alzheimer’s field is one of the areas of research that will be looked back upon with disillusionment.
    Tau tangles and beta plaques have been fiercely and dogmatically pursued as causes and therapeutic targets of Alzheimer’s disease. However, it is becoming increasingly clear that these aggregations are likely a consequence of the disease that does not necessarily present an avenue for therapy. I.e. the harmful part of the disease probably acts upstream of or in parallel to the accumulation of the tau and beta aggregations

    • Snowflake@sh.itjust.works
      link
      fedilink
      arrow-up
      24
      ·
      5 months ago

      All because Sylvain Lesné and team published a fraudulent research paper in 2006. The field has possibly lost a decade of time and money.

      • amenji@programming.dev
        link
        fedilink
        arrow-up
        12
        ·
        5 months ago

        TIL. Damn.

        Reminds me of the how early the covid policies were based on age-old misconceptions about aerosols.